A plasma miRNA signature, including miR‐495, as early diagnostic biomarkers associated with cognitive decline in Alzheimer's disease
Alterations in plasma miR-495 levels are reported for the first time in AD patients.miR-181a, miR-181c, and miR-495 levels were higher in AD patients compared to controls.Higher levels of these miRNAs were related to worse cognitive test scores.miRNA signature was able to distinguish AD stages.
Authors
- Gemma Carreras‐Badosa (ORCID: https://orcid.org/0000-0003-2100-0221)
- Elisabet Kádár (ORCID: https://orcid.org/0000-0001-9135-4637)
- Soleil García‐Brito (ORCID: https://orcid.org/0000-0002-4292-3212)
- Josep Puig (ORCID: https://orcid.org/0000-0003-2791-6599)
- Josep Garre‐Olmo (ORCID: https://orcid.org/0000-0002-7817-0814)
- Rafel Ramos (ORCID: https://orcid.org/0000-0001-7970-5537)
- Imma Pericot Nierga (ORCID: https://orcid.org/0000-0003-0621-4264)
- Gemma Huguet (ORCID: https://orcid.org/0000-0002-1439-5053)
- José Manuel Fernández‐Real (ORCID: https://orcid.org/0000-0002-7442-9323)
- Andrea Riberas‐Sánchez (ORCID: https://orcid.org/0000-0002-1980-5250)
- Antoni Turon
- Anna Cots (ORCID: https://orcid.org/0000-0002-9169-7653)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universitat de Girona (ES)
- Instituto de Salud Carlos III (ES)
- Institut d'Investigació Biomèdica de Girona (ES)
- Hospital Clínic de Barcelona (ES)
- Hospital Santa Caterina (ES)
- Institut Universitari d'Investigació en Atenció Primària Jordi Gol (ES)
- Hospital Universitari de Girona Doctor Josep Trueta (ES)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70213
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitat de Girona
- Generalitat de Catalunya
- Ministerio de Ciencia e Innovación