CD40 transcriptomic expression patterns across malignancies: implications for clinical trials of CD40 agonists
High CD40 expression correlated with liver and bile duct, pancreatic, and ovarian cancers, as well as with CD28 and GITR transcripts. Immune marker co-expression in individual patients merits further exploration for the development of CD40-based and other immunotherapy interventions.
Authors
- Taylor J. Jensen (ORCID: https://orcid.org/0000-0002-7206-7656)
- Jason K. Sicklick (ORCID: https://orcid.org/0000-0003-4403-0271)
- Daisuke Nishizaki (ORCID: https://orcid.org/0000-0002-6746-3224)
- Yuji Uehara (ORCID: https://orcid.org/0000-0001-8047-8730)
- Paul DePietro (ORCID: https://orcid.org/0000-0001-9072-0631)
- Razelle Kurzrock (ORCID: https://orcid.org/0000-0003-4110-1214)
- Hirotaka Miyashita (ORCID: https://orcid.org/0000-0002-0433-9779)
- Suzanna Lee (ORCID: https://orcid.org/0000-0002-9502-4907)
- Sarabjot Pabla (ORCID: https://orcid.org/0000-0002-7746-9144)
- Heidi Ko (ORCID: https://orcid.org/0000-0002-7247-9175)
- Yu Fujiwara (ORCID: https://orcid.org/0000-0003-1406-2352)
- Shumei Kato (ORCID: https://orcid.org/0000-0003-1193-1815)
Institutions
- Dartmouth College (US)
- University of Nebraska at Omaha (US)
- Roswell Park Comprehensive Cancer Center (US)
- Medical College of Wisconsin (US)
- Society for Immunotherapy of Cancer (US)
- UC San Diego Health System (US)
- LabCorp (United States) (US)
- Tokyo Metropolitan Komagome Hospital (JP)
- University of California San Diego (US)
- National Cancer Centre Japan (JP)
- National Cancer Center (US)
- Dartmouth Psychiatric Research Center (US)
- Regional Cancer Center (US)
- National Cancer Research Institute (GB)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1007/s00262-025-04197-8
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.80