Tumor microenvironment remodeling across thyroid cancer differentiation states revealed by spatial transcriptomics
These findings suggest that dedifferentiation in thyroid cancer is associated with an immunosuppressive TME that promotes tumor progression. Therapeutic strategies targeting JAK-STAT and VEGF pathways, or enhancing NK cell activity, may hold promises for aggressive thyroid cancers. Further studies with larger cohorts are necessary to validate these findings and develop targeted therapies for aggressive thyroid cancers.
Authors
- Dongjoo Lee (ORCID: https://orcid.org/0000-0001-9381-0376)
- Seog Yun Park (ORCID: https://orcid.org/0000-0002-5704-646X)
- Jungirl Seok (ORCID: https://orcid.org/0000-0001-6473-6015)
- Hongyoon Choi (ORCID: https://orcid.org/0000-0002-8895-2449)
- Chang Hwan Ryu (ORCID: https://orcid.org/0000-0001-8150-5163)
- Junsun Ryu (ORCID: https://orcid.org/0000-0002-6730-6755)
- Eun Kyung Lee (ORCID: https://orcid.org/0000-0003-4207-2080)
- Yuh‐Seog Jung (ORCID: https://orcid.org/0000-0002-9467-4916)
Institutions
- Seoul National University Hospital (KR)
- National Cancer Center (US)
- National Cancer Center (KR)
- National Health Insurance Service Ilsan Hospital (KR)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1007/s00262-025-04210-0
- Citations
- 2
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- National Research Foundation
- Ministry of Education
- National Research Foundation of Korea