Multi-Omics and Mendelian-Randomization Investigation of Mitochondrial Genes in Irritable Bowel Syndrome
This study represents the first application of multi-omics techniques to elucidate the relationship between mitochondrial genes and IBS. The findings indicate multiple candidate pathogenic genes and highlight the role of mitochondrial dysfunction in IBS pathogenesis. These findings offer new opportunities for the discovery of IBS biomarkers and the development of therapeutic strategies.
Authors
- Yi Huang (ORCID: https://orcid.org/0000-0001-7608-4843)
- Ji Zhang
- Xuejian Weng
- Xiuyan Wang (ORCID: https://orcid.org/0000-0002-1551-3330)
- Beibei Xu
- Yingcong Yu (ORCID: https://orcid.org/0000-0001-8705-9678)
- Miaomiao Teng
- Endian Zheng
Institutions
- Shanghai University (CN)
- Shanghai University of Engineering Science (CN)
- Wenzhou Medical University (CN)
- Ruian People's Hospital (CN)
- Wenzhou City People's Hospital (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-10-29
- DOI
- https://doi.org/10.2174/0109298673409785250925143312
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00