Aberrant hippocampal gamma oscillations in a mouse model of fragile X syndrome: insights from in vitro slice models
Our findings demonstrate that hippocampal gamma oscillations are differentially affected by distinct neuromodulatory pathways in Fmr1 KO mice. Enhanced responsiveness to cholinergic and mGluR activation and reduced coherence of KA-induced rhythms suggest that multiple dysregulated mechanisms contribute to gamma oscillopathies in FXS.
Authors
- Evangelia Pollali
- Jan‐Oliver Hollnagel (ORCID: https://orcid.org/0000-0002-4060-0022)
- Miguel del Ángel (ORCID: https://orcid.org/0000-0002-8669-0473)
- Yunus Emre Demiray (ORCID: https://orcid.org/0000-0002-9617-5723)
- Gürsel Çalışkan (ORCID: https://orcid.org/0000-0003-4832-0807)
- Sara Enrile Lacalle
- Anil Annamneedi (ORCID: https://orcid.org/0000-0002-6743-8627)
- Daniel Frías Donaire
Institutions
- Periyar University (IN)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Center for Behavioral Brain Sciences (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Molecular Autism
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1186/s13229-025-00687-9
- Citations
- 2
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Deutsche Forschungsgemeinschaft
- Leibniz-Gemeinschaft
- European Regional Development Fund
- European Social Fund