Altered Sigmoid Mucosal Innervation and Mast Cell Proximity to Sensory Nerve Fibers Are Associated With Symptom Severity in Patients With Irritable Bowel Syndrome
In IBS, there are reduced densities of colonic enteric cholinergic and intrinsic primary afferent NFs. Correlations between abdominal pain severity and MC-NF interactions in IBS patients suggest that altered neuroimmune signaling may contribute to IBS pathophysiology and represent a potential therapeutic target.
Authors
- Michael J. Nash (ORCID: https://orcid.org/0000-0002-4390-4531)
- Yvette Taché (ORCID: https://orcid.org/0000-0002-1044-5279)
- Ariela Khandadash
- Jessica Sohn
- Lin Chang (ORCID: https://orcid.org/0000-0001-6800-2967)
- Pu‐Qing Yuan (ORCID: https://orcid.org/0000-0002-0067-510X)
- Swapna Mahurkar‐Joshi (ORCID: https://orcid.org/0000-0001-9591-4590)
- Tao Li (ORCID: https://orcid.org/0000-0002-9174-1271)
Institutions
- University of California, Los Angeles (US)
- VA Greater Los Angeles Healthcare System (US)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1111/nmo.70199
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.81
Funders
- Scheme for Promotion of Academic and Research Collaboration
- National Institutes of Health