PHF10 is a Novel Substrate of Keap1 to Protect Non-Small-Cell Lung Cancer (NSCLC) Cells Against Oxidative Stress and Confer Ferroptosis Resistance
Together, our study highlight the synthetic lethal relationship between Keap1 and PHF10, and provide targeting PHF10-SMARCA2 complex as an effective option to hit Keap1-deficient NSCLC.
Authors
- Yong Yang (ORCID: https://orcid.org/0000-0001-7642-1299)
- Donglin Zhu (ORCID: https://orcid.org/0000-0002-4001-8374)
- Xiaohong Lu (ORCID: https://orcid.org/0000-0001-6417-0250)
- Yajun Chen (ORCID: https://orcid.org/0000-0003-3132-2945)
- Jun Yang (ORCID: https://orcid.org/0000-0003-3287-4995)
- Xiaoshan Zhao
- Hongya Xie (ORCID: https://orcid.org/0000-0003-1669-0096)
- Ningning Kang
Institutions
- Hefei Normal University (CN)
- Anhui Medical University (CN)
- Suzhou Municipal Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cancer Research and Treatment
- Published
- 2025-11-03
- DOI
- https://doi.org/10.4143/crt.2025.635
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health