m6A-mediated silencing of RNF41 by METTL3/YTHDC1 disrupts autophagy to drive intervertebral disc degeneration
METTL3/YTHDC1-mediated m6A modification drives IDD progression by silencing RNF41, thereby impairing autophagy and ECM integrity. Targeting this axis offers a clinically actionable strategy to delay disc degeneration, particularly in patients with early-stage IDD. This evidence establishes RNF41's role as a theragnostic biomarker and therapeutic targe, enabling precision-guided interventional approaches.
Authors
- Zhengyu Chen (ORCID: https://orcid.org/0000-0002-0487-5037)
- Bo Yao (ORCID: https://orcid.org/0000-0002-2193-2347)
- Ziwei Han (ORCID: https://orcid.org/0000-0002-0168-1026)
- Weiguo Wang (ORCID: https://orcid.org/0000-0002-3782-9133)
- Li Wan (ORCID: https://orcid.org/0000-0002-9747-4346)
- Lei Zhao (ORCID: https://orcid.org/0000-0002-1441-5528)
- Jia Deng
Institutions
- Central South University (CN)
- Third Xiangya Hospital (CN)
- Hunan Institute of Mental Health (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-11-03
- DOI
- https://doi.org/10.1007/s10565-025-10093-9
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81