Thiol centric enzyme mimetic catalysis within MIL-47 (V) accelerates sulfur redox and enhances stability for lean electrolyte lithium–sulfur batteries

Designing tailored multifunctional catalysts that enhance lean-electrolyte sulfur redox kinetics is crucial for achieving high-energy-density lithium-sulfur batteries, however, still remains challenge. Motivated by the structural protection of active sites in natural enzymes, we implant natural glutathione (GSH) within the metal-organic framework MIL-47 (V) cavity for GSH@MIL-47 (V) biomimetic catalysts, thereby stabilizing and activating its thiol functionality.&nbsp;Quantification using DTNB as a probe confirmed successful GSH incorporation, revealing that GSH@MIL-47 (V) enables a continuous and stable catalytic reaction cycle. Moreover, <em>in-situ</em>&nbsp;and <em>ex-situ</em>&nbsp;spectroscopies indicate thiol-driven S-S bond breakage that lowers the reaction energy barrier and concurrently promote LiTFSI decomposition. As a result, GSH@MIL-47 (V) cells, at 6 C rate, deliver a discharge capacity of 733.1 mAh g^-1&nbsp;and maintain 573.0 mAh g^-1&nbsp;after 750 cycles. Even under an electrolyte-to-sulfur ratio of 5.5&nbsp;μL mg^-1, it maintains 867.2 mAh g^-1&nbsp;at a high-rate of 0.5 C. This strategy highlights the potential of enzyme-inspired catalysts for enhancing lithium-sulfur batteries.