Serine Promotes Inflammatory Macrophage Polarisation in Periodontitis via <scp>NAD</scp> <sup>+</sup> Signalling
Serine-induced inflammatory macrophage polarisation, mediated through NAD<sup>+</sup> signalling, plays a key role in periodontitis pathogenesis. Targeting serine transport and NAD<sup>+</sup> metabolism may offer new therapeutic strategies for managing periodontitis.
Authors
- Qiming Zhai
- Sijing Zhao (ORCID: https://orcid.org/0000-0002-4768-6527)
- Heng Ye (ORCID: https://orcid.org/0000-0001-5183-3174)
- Richard D. Cannon (ORCID: https://orcid.org/0000-0002-5398-2066)
- Hongmei Zhang (ORCID: https://orcid.org/0000-0002-3467-2898)
- Xiang Liu (ORCID: https://orcid.org/0000-0001-6046-1405)
- Hua Zhang (ORCID: https://orcid.org/0000-0003-2875-7243)
- Lei Xu (ORCID: https://orcid.org/0009-0003-7693-5793)
- Chang Chen (ORCID: https://orcid.org/0000-0003-1674-973X)
- Ping Ting Ji (ORCID: https://orcid.org/0000-0002-2608-1035)
- Yunying He
- Lingli Fang
- Jing Xiang (ORCID: https://orcid.org/0000-0003-1361-7176)
- Jun Wang (ORCID: https://orcid.org/0000-0002-7437-8503)
Institutions
- Stomatological Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical and Pharmaceutical College (CN)
- University of Otago (NZ)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal Of Clinical Periodontology
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1111/jcpe.70058
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00