A little “ <scp>BiTS</scp> ” of <scp>LAG3</scp> agonism, a big effect on T‐cell autoimmunity
LAG3-MHC-II binding recruits LAG3 to the immune synapse, suppressing T-cell activation through induced formation of condensates between the LAG3 intracellular domain and that of the CD3ε subunit. The BiTS molecule designed by Du et al. mimics the effect of MHC-II binding by tethering LAG3 to the TCR.
Authors
- Vincent C. Luca (ORCID: https://orcid.org/0000-0001-9427-5520)
- Qianqian Ming (ORCID: https://orcid.org/0000-0003-0296-7859)
Institutions
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Immunology and Cell Biology
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1111/imcb.70065
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute