Combined inhibition of the complement component C5 and the TLR-coreceptor CD14 alters the posttraumatic response in fracture hematoma in a porcine polytrauma model
These findings show that systemic C5/CD14 inhibition effectively reduced the concentration of several pro-inflammatory proteins in the systemic circulation and locally, at the fracture site, in the fracture hematoma. The levels in the plasma were in line with those in the fracture hematoma, albeit that they were markedly lower in the plasma compared to the fracture hematoma.
Authors
- Frank Hildebrand (ORCID: https://orcid.org/0000-0001-7729-9838)
- Markus Huber‐Lang (ORCID: https://orcid.org/0000-0003-2359-6516)
- Rald V. M. Groven (ORCID: https://orcid.org/0000-0001-8733-289X)
- Juliane M. Nies
- Tom Eirik Mollnes (ORCID: https://orcid.org/0000-0002-5785-802X)
- Martijn van Griensven (ORCID: https://orcid.org/0000-0001-5104-9881)
- Felix Bläsius (ORCID: https://orcid.org/0000-0001-7419-8687)
- Klemens Horst (ORCID: https://orcid.org/0000-0002-7162-6153)
- Johannes Greven (ORCID: https://orcid.org/0000-0003-2856-4804)
- Ümit Mert (ORCID: https://orcid.org/0000-0001-6125-6040)
- Dong Chen (ORCID: https://orcid.org/0000-0002-7102-6836)
Institutions
- Oslo University Hospital (NO)
- Maastricht University (NL)
- Nordland Hospital (NO)
- University Hospital Ulm (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Innovative Surgical Sciences
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1515/iss-2025-0031
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00