Improving the oral bioavailability and anti-inflammatory potential of clove oil-derived β-caryophyllene with a self-nanoemulsifying drug delivery system
β-Cary showed significant anti-inflammatory activity by inhibiting leukocyte migration to the inflamed site. Its β-SNEDDS formulation improved oral bioavailability and additional anti-inflammatory parameters in vivo, beyond those achieved by β-Cary, supporting this approach as a promising oral strategy.
Authors
- Jurandir Fernando Comar (ORCID: https://orcid.org/0000-0002-9518-7589)
- Tiane C. Finimundy (ORCID: https://orcid.org/0000-0003-3516-0795)
- Adelar Bracht (ORCID: https://orcid.org/0000-0002-8098-5705)
- Lillian Barros (ORCID: https://orcid.org/0000-0002-9050-5189)
- Ana Paula Ames-Sibin (ORCID: https://orcid.org/0000-0001-6966-1665)
- Lívia Bracht (ORCID: https://orcid.org/0000-0003-3315-3540)
- Juliana Cristina Castro (ORCID: https://orcid.org/0000-0002-7888-2731)
- Marcos Luciano Bruschi (ORCID: https://orcid.org/0000-0002-4838-5742)
- Anacharis Babeto de Sá‐Nakanishi (ORCID: https://orcid.org/0000-0002-2300-1861)
- Francielli Maria de Souza Silva
- Sabrina Barbosa de Souza Ferreira (ORCID: https://orcid.org/0000-0001-8364-0449)
- Any Carolina Chagas-Ameida
Institutions
- Universidade Estadual de Maringá (BR)
- Centro Universitário Cesumar (BR)
- Universidade Politécnica de Bragança (PT)
Publication Details
- Journal
- Journal of Pharmacy and Pharmacology
- Published
- 2025-10-08
- DOI
- https://doi.org/10.1093/jpp/rgaf105
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00