Curcumin suppresses EMT to alleviate oral submucous fibrosis progression through XIST/miR-25-3p-mediated inactivation of the TGF-β1/Smads signalling pathway
Curcumin effectively inhibits EMT by inactivating the TGF-β1/Smads pathway through regulating XIST/miR-25-3p, and thereby alleviating the progression ofOSF. The study results further reveal the mechanisms underlying the function of curcumin, and may provide novel targets and ideas for OSF therapy.
Authors
- Jian Qin (ORCID: https://orcid.org/0000-0002-5225-6169)
- Yue Zhao (ORCID: https://orcid.org/0000-0002-0947-2843)
- Min Qian (ORCID: https://orcid.org/0000-0003-1214-8830)
- Jian Liu (ORCID: https://orcid.org/0000-0001-9719-2923)
- Yao Liu (ORCID: https://orcid.org/0000-0003-1782-7322)
Institutions
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Jinan Stomatological Hospital (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.identj.2025.103975
- Citations
- 1
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47