IGZO thin-film transistor biosensor array for highly sensitive detection of β2-microglobulin
β2-Microglobulin (β2-MG) is a sensitive indicator of chronic kidney disease. Traditional analytical methods like radioimmunoassay and enzyme-linked immunosorbent assay exhibit critical drawbacks, including complex operation procedures, time-consuming processes, and limited sensitivity. Biosensors provide a simple, rapid, and accurate strategy for β2-MG detection. Among them, thin-film transistors (TFTs) are widely used in biosensing due to their high sensitivity, nanoscale size, and large-scale manufacturability. Herein, a 4 × 4 biosensor array based on indium gallium zinc oxide (IGZO) is successfully prepared. It is demonstrated that the biosensor exhibits high sensitivity to β2-MG, with a detection limit as low as 1.2 × 10<sup>-4</sup> μg mL<sup>-1</sup>. Furthermore, the biosensor exhibits high sensitivity, good consistency, and great practical application potential.
Authors
- Xiumin Gao (ORCID: https://orcid.org/0000-0002-9343-024X)
- Xuefeng Zhao (ORCID: https://orcid.org/0000-0002-1704-4021)
- Yongliang Deng (ORCID: https://orcid.org/0000-0002-0236-396X)
- Xinyue Zhang (ORCID: https://orcid.org/0000-0001-5338-1001)
- Wen Xiaohong
- Xiangmei Dong
- Xinle Han
Institutions
- University of Shanghai for Science and Technology (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Ceramics (CN)
Publication Details
- Journal
- Analytical Methods
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ay01278c
- Primary Topic
- Thin-Film Transistor Technologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00