Decoding epithelial regeneration in the cornea: multi-omic analysis reveals cellular plasticity as central mechanism
Our multi-omics analyses revealed extensive epithelial cellular plasticity as a key mechanism driving rapid wound closure, characterized by profound remodeling of transcriptional networks and RNA modifications. Importantly, we uncovered a previously underappreciated role of the lacrimal gland and tear film in mediating bilateral molecular responses following unilateral injury, emphasizing their pivotal roles in tissue regeneration. Additionally, we identified novel regulatory roles for RNA methylation events and critical signaling pathways implicated in epithelial healing.
Authors
- Naïma Nhiri
- Vincent Daïen (ORCID: https://orcid.org/0000-0001-5675-0861)
- Ophir D. Klein (ORCID: https://orcid.org/0000-0002-6254-7082)
- Frédéric Michon (ORCID: https://orcid.org/0000-0003-4305-305X)
- Sílvia Llorens (ORCID: https://orcid.org/0000-0002-2104-5414)
- Nadège Feret
- Christophe Hirtz (ORCID: https://orcid.org/0000-0002-7313-0629)
- Jérôme Vialaret (ORCID: https://orcid.org/0000-0002-3730-2366)
- Pauline Marangoni (ORCID: https://orcid.org/0000-0002-4355-7322)
- Eric Jacquet (ORCID: https://orcid.org/0000-0001-6366-8436)
- Alison Kuony (ORCID: https://orcid.org/0000-0001-9132-4921)
- Alexandre David (ORCID: https://orcid.org/0000-0003-3365-1339)
- Karine Loulier (ORCID: https://orcid.org/0000-0001-6216-2708)
- Laura Fichter
- Alicia Caballero Megido
- Aurore Attina (ORCID: https://orcid.org/0009-0001-5261-7438)
Institutions
- Roche (Switzerland) (CH)
- Centre National de la Recherche Scientifique (FR)
- The University of Sydney (AU)
- Institut de Chimie des Substances Naturelles (FR)
- Inserm (FR)
- University of California, San Francisco (US)
- Université de Montpellier (FR)
- Université Paris-Saclay (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Hôpital Gui de Chauliac (FR)
- Institute for Neurosciences of Montpellier (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1186/s11658-025-00804-9
- Citations
- 3
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- Helsingin Yliopisto
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Université de Montpellier
- Biocenter Finland
- Région Occitanie Pyrénées-Méditerranée