Plasma extracellular vesicles-derived microRNAs provide potential biomarkers in distinguishing between focal cortical dysplasia type I and II
Lesional characteristics, surgical approaches, and prognosis are different between FCD type I and II. Eight differentially expressed miRNAs in plasma extracellular vesicles between FCD type I and II were identified. Target genes of these miRNAs were significantly enriched in immune and inflammatory responses and cytokine pathways. The identified miRNAs may represent potential pre-operative biomarkers for FCD subtyping, potentially guiding surgical strategies and outcome prediction, especially for FCD type II. Extracellular vesicle-mediated immune responses may differ between FCD type I and II, offering insight into FCD pathogenesis, epileptogenic mechanisms, and the identification of novel therapeutic targets.
Authors
- Qingzhu Liu (ORCID: https://orcid.org/0000-0002-9695-2246)
- Yu Sun (ORCID: https://orcid.org/0000-0002-3568-2238)
- Taoyun Ji (ORCID: https://orcid.org/0000-0003-0098-3257)
- Huaiyuan Wang (ORCID: https://orcid.org/0009-0007-6004-0433)
- Ye Wu (ORCID: https://orcid.org/0000-0001-9644-9520)
- Lixin Cai (ORCID: https://orcid.org/0000-0001-8231-6428)
- Yuwu Jiang (ORCID: https://orcid.org/0000-0002-5179-9807)
- Chang Liu (ORCID: https://orcid.org/0000-0002-0792-6987)
- Yao Wang (ORCID: https://orcid.org/0000-0003-1074-5375)
- Xiaoyan Liu (ORCID: https://orcid.org/0000-0002-8276-907X)
- Shuang Wang (ORCID: https://orcid.org/0000-0003-2962-6798)
- Hao Yu (ORCID: https://orcid.org/0000-0002-5164-4792)
- Yi Wang (ORCID: https://orcid.org/0000-0002-4775-5457)
- Bolin Zhou (ORCID: https://orcid.org/0009-0002-6015-1743)
- Ruofan Wang (ORCID: https://orcid.org/0000-0002-0602-704X)
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1038/s41390-025-04343-z
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University First Hospital
- Peking University