Combination of minocycline and ciprofloxacin enhances the inhibitory effect of tumor necrosis factor-alpha production in lipopolysaccharide-stimulated THP-1 monocytic cells
Combination therapy with MINO and CPFX enhanced the inhibitory effects on inflammatory cytokine and chemokine production <i>in vitro</i>. This combination therapy is expected to provide both antimicrobial and anti-inflammatory effects. Enhanced cytokine modulation by antibiotics may be a key mechanism in the treatment of severe infectious diseases such as JSF.
Authors
- Ippei Sakamaki (ORCID: https://orcid.org/0000-0002-7160-5635)
- Hiromichi Iwasaki (ORCID: https://orcid.org/0000-0001-6206-9263)
- Yukië Tanaka
Institutions
- University of Fukui (JP)
- University of Fukui Hospital (JP)
Publication Details
- Journal
- Infectious Medicine
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1016/j.imj.2025.100214
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00