HMGB1 promotes LPS-induced M1 polarization and apoptosis in microglia by mediating the expression of immune and inflammation-related genes
HMGB1 may drive microglia toward a pro-inflammatory M1 phenotype, thereby mediating neuroinflammatory damage in POCD, potentially through activation of STAT, TNF, and IL-17 signaling pathways. Targeting HMGB1 and its downstream genes (e.g., Ccl22, Lcn2, Stat5a, Tlr2, Cd74, Egr2) could provide effective diagnostic and interventional strategies for POCD.
Authors
- Fan Yang (ORCID: https://orcid.org/0009-0002-2260-5476)
- Xiang Cui (ORCID: https://orcid.org/0000-0003-4120-2672)
- Qi Huang (ORCID: https://orcid.org/0000-0002-9425-6618)
- Na Li (ORCID: https://orcid.org/0000-0002-6227-8433)
- Li Zhao (ORCID: https://orcid.org/0000-0003-3599-8934)
- Huiwen Zhang (ORCID: https://orcid.org/0000-0003-4657-5494)
- Lin Ma (ORCID: https://orcid.org/0000-0003-3041-5605)
- Wan‐Wan Lin (ORCID: https://orcid.org/0000-0002-3207-734X)
- Ma HanXiang (ORCID: https://orcid.org/0009-0002-7385-013X)
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111615
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68