Increased gut Saccharomyces and decreased pathogenic fungi associated with food protein–induced enterocolitis syndrome resolution

This study identified distinct mycobiome profiles in children with current versus resolved FPIES. Resolved FPIES was associated with <i>Saccharomyces</i> enrichment, whereas children with current FPIES had more diverse, opportunistic pathogen-associated communities and greater infant antibiotic and proton pump inhibitor usage. Although these associations do not establish causality, they underscore the need for larger, longitudinal studies to determine whether the mycobiome and early-life exposures influence FPIES outcomes, because it could have implications for treatment and prevention.