From Metro Ticket to a Cape-to-Khartoum Pass: Reimagining Liver Transplantation Criteria for HCC in Sub-Saharan Africa
This study highlights the potential limited applicability of current LT criteria in SSA, where applying criteria, less than 5% of HCC patients qualify. We propose a novel Cape-to-Khartoum framework incorporating clinical and biological parameters, including tumour markers, tumour differentiation and multi-omic profiling. This model may broaden LT eligibility and improve outcomes for HCC in SSA and warrants further validation through multicentre studies across the region.
Authors
- E Keli
- Inae Kim (ORCID: https://orcid.org/0000-0003-2783-3267)
- C Wendy Spearman (ORCID: https://orcid.org/0000-0003-3199-301X)
- Tinus Du Toit (ORCID: https://orcid.org/0000-0002-8840-9032)
- Abdelmounem Abdo (ORCID: https://orcid.org/0000-0002-4726-4738)
- Mark Wayne Sonderup (ORCID: https://orcid.org/0000-0001-7128-8329)
- Luiz F. Zerbini (ORCID: https://orcid.org/0000-0003-0736-9508)
- Eduard Jonas (ORCID: https://orcid.org/0000-0003-0123-256X)
- M. Bernon (ORCID: https://orcid.org/0000-0002-7967-8548)
- Christian Tzeuton
- U. Kotze (ORCID: https://orcid.org/0000-0003-1405-474X)
- Sanju Sobnach (ORCID: https://orcid.org/0000-0002-4456-2115)
- Muhammad Emmamally (ORCID: https://orcid.org/0009-0005-2148-685X)
Institutions
- University of Cape Town (ZA)
- University of Douala (CM)
- Institut Universitaire d'Abidjan (CI)
- International Centre for Genetic Engineering and Biotechnology (ZA)
- National Centre for Research (Sudan) (SD)
Publication Details
- Journal
- Transplantation Proceedings
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1016/j.transproceed.2025.10.021
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00