Dendrobine alleviates CCl4-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways
This study demonstrates that DDB inhibits mtROS and p-MLKL through the Nrf2/PPARγ/SOD2 signaling axis, thereby suppressing necroptosis and ameliorating ALI.
Authors
- Ling Tan (ORCID: https://orcid.org/0000-0002-4748-3447)
- Siting Xian
- Xiaolong Fu (ORCID: https://orcid.org/0000-0002-3884-0916)
- Yonggang Yang
- Jingshan Shi (ORCID: https://orcid.org/0000-0002-2537-1751)
- Letao Hu
- Qiwei Gan (ORCID: https://orcid.org/0000-0002-6830-9544)
- Nan Nan
- Qin Wu (ORCID: https://orcid.org/0000-0001-5264-9926)
- Shaoyu Zhou (ORCID: https://orcid.org/0009-0000-3580-0348)
- Naiyu Fan
Institutions
- Zunyi Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-11-02
- DOI
- https://doi.org/10.1186/s13020-025-01241-8
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56