Rectal Fidaxomicin as Salvage Therapy in Fulminant Clostridioides difficile Infection After Total Colectomy: A Case Report

An extensive review of the literature found only a few instances of rectal fidaxomicin use for FCDI, suggesting its novelty and rarity. The successful outcome prompts further studies to validate its efficacy and its possible inclusion in future treatment guidelines. In summary, this case underscores the complexity of FCDI management and highlights the potential of rectal fidaxomicin as a salvage therapy. Further research is warranted to elucidate its role in treating FCDI and incorporating it into clinical practice guidelines.