Functional analysis of FH variants of uncertain significance using Caenorhabditis elegans model

We showed that <i>C. elegans</i> could be reliably used for the reclassification of VUS in <i>FH</i>. Importantly, our proposed methodology based on the nematode's quick generation cycle, ease of strain creation, and phenotypic readouts opens the door for future studies on <i>FH</i> using <i>C. elegans</i>, including genotype-phenotype correlation and background effects.