Synthesis of chiral α-alkynyl-α-hydroxyamides by enantioselective alkynylation of α-keto amides
The α-hydroxyamide moiety is an important structural component in a wide variety of biologically active compounds and natural products. Herein, we describe a highly efficient and practical approach towards chiral quaternary α-alkynyl-α-hydroxyamides by Me<sub>2</sub>Zn-mediated addition of terminal alkynes to α-keto amides. The desired products are obtained in good yields and enantioselectivities with broad substrate and reagent scopes.
Authors
- Celia Andrés (ORCID: https://orcid.org/0000-0003-1583-7439)
- Javier Nieto (ORCID: https://orcid.org/0000-0002-5655-3320)
- Elena Prieto (ORCID: https://orcid.org/0000-0002-0248-7938)
Institutions
- Universidad de Valladolid (ES)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob01546d
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Junta de Castilla y León