Impact of trehalose and hydroxychloroquine on the function of BRAF (V600E)-siRNA in the A375 melanoma cells.
TRE, either alone or combined with siRNA, showed limited efficacy and may counteract the apoptotic benefits of HCQ. Conversely, HCQ, whether used alone or in combination with siRNA, enhanced apoptosis, suggesting promise as a potential treatment for melanoma.
Authors
- Mohammadreza Sharifi (ORCID: https://orcid.org/0000-0002-1538-9034)
- Fatemeh Tabandeh (ORCID: https://orcid.org/0000-0002-4989-7598)
- Rana Moradian Tehrani (ORCID: https://orcid.org/0000-0001-9733-6528)
- Seyedeh Negin Hadisadegh
- Elmira Toobchi
Institutions
- Isfahan University of Medical Sciences (IR)
- Tarbiat Modares University (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.85017.18394
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00