Elucidating the effect of deferoxamine, a hypoxia mimetic agent, on angiogenesis restoration in endothelial progenitor cells (EPCs) from diabetic mice.
DFO reactivates proliferation and restores the impaired angiogenic properties of EPCs from diabetic mice by stabilizing HIF-1α and VEGF. Additionally, DFO enhanced the pro-angiogenic activity in the EPC-secretome, leading to improved wound healing. This improvement is attributed to the dual activation of HIF-1α /VEGF and Ang-1/Tie2 pathways, which are crucial for initiating and maturing new blood vessels.
Authors
- Vahid Siavashi (ORCID: https://orcid.org/0000-0003-1297-8295)
- Tunku Kamarul (ORCID: https://orcid.org/0000-0002-6028-1313)
- Seyed Mahdi Nassiri (ORCID: https://orcid.org/0000-0002-5746-9593)
- Ali Mohammad Sharifi (ORCID: https://orcid.org/0000-0002-5089-7122)
- Mahdi Farhadi Mahalli
Institutions
- Islamic Azad University, Science and Research Branch (IR)
- Iran University of Medical Sciences (IR)
- University of Tehran (IR)
- University of Malaya (MY)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.81969.17737
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Medical Research Development