Local modulation of sleep slow waves depends on timing between auditory stimuli
This distinction resolves inconsistencies in prior PTAS studies by demonstrating that phase alone is insufficient in predicting slow-wave responses. Rather, it was the ISI which determined whether PTAS resulted in a global, KC-mediated response or a local, phase-specific modulation of SWA. Consequently, our findings refine the mechanistic understanding of PTAS, suggesting that ISI regulates the engagement of distinct neural circuits and thereby potentially enables the targeted manipulation of specific slow-wave subtypes and their associated functions.
Authors
- Giulia Da Poian (ORCID: https://orcid.org/0000-0002-8960-1077)
- Sophia Snipes (ORCID: https://orcid.org/0000-0002-6353-0207)
- Elena Krugliakova (ORCID: https://orcid.org/0000-0001-7915-4560)
- Jelena Skoručak (ORCID: https://orcid.org/0000-0002-1288-6836)
- Maria Laura Ferster (ORCID: https://orcid.org/0000-0003-2745-5294)
- Sven Leach (ORCID: https://orcid.org/0000-0001-7425-4589)
- Walter Karlen (ORCID: https://orcid.org/0000-0001-8643-3074)
- Georgia Sousouri (ORCID: https://orcid.org/0000-0003-1547-3700)
- Sara Fattinger (ORCID: https://orcid.org/0000-0003-4866-8598)
- Reto Huber (ORCID: https://orcid.org/0000-0002-1400-9466)
- Selina Schühle
Institutions
- Centre National de la Recherche Scientifique (FR)
- Radboud University Nijmegen (NL)
- Inserm (FR)
- Universität Ulm (DE)
- University of Zurich (CH)
- Radboud University Medical Center (NL)
- ETH Zurich (CH)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- University Children's Hospital Zurich (CH)
- Institut du Cerveau (FR)
Publication Details
- Journal
- NeuroImage
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1016/j.neuroimage.2025.121561
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00