Troxerutin attenuates LPS-induced inflammation in BV2 microglial cells involving Nrf2 activation and NF-κB pathway inhibition.
TX suppresses pro-inflammatory induction after LPS stimulation of BV2 microglia, which may be related to the NF-κB inhibition and accelerated HO-1/Nrf2 activation. These findings pinpoint the potential therapeutic potential of TX in inflammation-induced neurodegenerative diseases.
Authors
- Lijun Wang (ORCID: https://orcid.org/0000-0002-5788-1414)
- Shengnan Ma (ORCID: https://orcid.org/0000-0003-4892-1557)
- Hongguang Fan
- Jianhong Zhang (ORCID: https://orcid.org/0000-0002-0194-1334)
- Changjun Li (ORCID: https://orcid.org/0000-0002-7265-4893)
- Hong Shi (ORCID: https://orcid.org/0000-0003-3776-498X)
Institutions
- Tianjin Fourth Central Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.87692.18941
- Primary Topic
- Antioxidants, Aging, Portulaca oleracea
- Type
- article
- Field-Weighted Citation Impact
- 0.00