Impact of molecular tests and precision oncology on patients with advanced thyroid carcinomas in a referral center: the OrienTHYring real-world study
Advanced TCs harbor a high prevalence of ESCAT I-III AMTs. Patients eligible for clinical trials with experimental drugs should undergo comprehensive genomic profiling and evaluation by an MTB to assess therapeutic actionability. A new biopsy is recommended for formalin-fixed, paraffin-embedded specimens older than 5 years to increase the likelihood of obtaining evaluable results.
Authors
- Imperia Nuzzolese (ORCID: https://orcid.org/0000-0001-6293-5301)
- A. Vingiani
- Massimo Milione (ORCID: https://orcid.org/0000-0002-1202-139X)
- Silvia Buriolla (ORCID: https://orcid.org/0000-0001-8076-856X)
- Laura D. Locati (ORCID: https://orcid.org/0000-0003-3315-2580)
- Luca Agnelli (ORCID: https://orcid.org/0000-0003-0582-6170)
- Biagio Paolini (ORCID: https://orcid.org/0000-0001-7535-7715)
- Carlo Resteghini (ORCID: https://orcid.org/0000-0002-0188-9759)
- Cristiana Bergamini (ORCID: https://orcid.org/0000-0001-7616-5125)
- I. Capone
- Sergio Alfieri (ORCID: https://orcid.org/0000-0002-7813-4426)
- Matteo Duca (ORCID: https://orcid.org/0000-0003-3968-5011)
- Lisa Licitra
- Marco Salvetti (ORCID: https://orcid.org/0000-0002-0501-8803)
- F Caspani
- Alessandro Piccolo (ORCID: https://orcid.org/0000-0002-5779-8581)
- Giuseppina Calareso (ORCID: https://orcid.org/0000-0002-9307-3975)
- Giancarlo Pruneri (ORCID: https://orcid.org/0000-0002-7963-7172)
- Stefano Cavalieri (ORCID: https://orcid.org/0000-0003-1294-6859)
- Elena Tamborini (ORCID: https://orcid.org/0000-0002-3819-8687)
- Elena Colombo (ORCID: https://orcid.org/0000-0002-5265-5055)
- Arianna Ottini
- Franco Perrone
Institutions
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
Publication Details
- Journal
- ESMO Open
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1016/j.esmoop.2025.105856
- Citations
- 1
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.29