Pretreatment with a ketogenic diet inhibits mitochondrial damage in rat models of spinal cord injury via the PGC-1α/Sirt1/Nrf1 pathway.
KD pretreatment enhances SCI recovery by modulating the PGC-1α/Sirt1/Nrf1 pathway, improving mitochondrial function, and reducing neuronal death. The study provides new insights into the mechanisms of KD.
Authors
- Xiaomeng Wang (ORCID: https://orcid.org/0000-0002-4516-4389)
- Lan Wang (ORCID: https://orcid.org/0009-0005-0235-8254)
- Haichuan Lu
- Yang Liao (ORCID: https://orcid.org/0009-0001-1341-0493)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.82683.18565
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00