Causal relationship between fatty acid metabolism and allergic asthma: a mendelian randomization and multi-omics study
This multi-omics integration study pioneers in delineating fatty acid metabolic reprogramming as a central mechanism in AAS pathogenesis. The identified ACACB-ADRB3 axis presents a novel therapeutic target, while dietary modulations of metabolite profiles offer promising avenues for personalized prevention strategies, advancing precision medicine in asthma management.
Authors
- Kai Yang (ORCID: https://orcid.org/0000-0002-0443-4493)
- Lixia Yang (ORCID: https://orcid.org/0000-0002-0982-9881)
- ShangRao Mo
- Jinyue Wang (ORCID: https://orcid.org/0000-0001-6184-9129)
- Xiao Li (ORCID: https://orcid.org/0000-0002-3036-5663)
- Yong Xie (ORCID: https://orcid.org/0009-0003-1575-4104)
Institutions
- North Sichuan Medical University (CN)
- Chengdu Medical College (CN)
- Sichuan University (CN)
- Chengdu University of Information Technology (CN)
- Chengdu University (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
- Nanchong Central Hospital (CN)
- Sichuan University of Science and Engineering (CN)
Publication Details
- Journal
- Journal of Asthma
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1080/02770903.2025.2580995
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00