Genomic characterization of blaOXA-48–carrying IncL plasmids in Enterobacterales in Vietnam
Carbapenem-hydrolyzing β-lactamase (carbapenemase) genes have been disseminated among bacteria worldwide; however, only a few instances of bacterial isolates harboring the carbapenemase gene <i>bla</i> <sub>OXA-48</sub> have been reported in Vietnam. Here we report the first genetic characterization of <i>bla</i> <sub>OXA-48</sub> -harboring <i>Enterobacterales</i> isolates in Vietnam. Three isolates- <i>Enterobacter hormaechei</i> , <i>Klebsiella pneumoniae</i> , and <i>Escherichia coli</i> -were clinically collected in Hanoi between 2010 and 2015. Whole-genome sequencing revealed that these isolates carried <i>bla</i> <sub>OXA-48</sub> on nearly identical IncL plasmids, closely related to globally disseminated pOXA-48a-like plasmids. Our findings highlight the potential spread of highly transmissible <i>bla</i> <sub>OXA-48</sub> -carrying plasmids in Vietnam, emphasizing the importance of continued surveillance.
Authors
- Hai Anh Tran (ORCID: https://orcid.org/0000-0002-1437-3516)
- H. Rogier van Doorn (ORCID: https://orcid.org/0000-0002-9807-1821)
- Keigo Shibayama (ORCID: https://orcid.org/0000-0002-1233-6842)
- Tran Huy Hoang (ORCID: https://orcid.org/0000-0002-4133-9874)
- Masato Suzuki (ORCID: https://orcid.org/0000-0001-8975-2193)
- Linh Dieu Tran
- Duc Anh Dang (ORCID: https://orcid.org/0000-0002-8029-9860)
- Duy Thai Pham
- Nhu Duong Tran
Institutions
- National Institute of Infectious Diseases (JP)
- National Institute Of Hygiene And Epidemiology (VN)
- Nagoya University (JP)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-14
- DOI
- https://doi.org/10.17912/micropub.biology.001603
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00