Impaired Speaking-Induced Suppression Predicts Degraded Agency and Hallucination Severity in Schizophrenia
Patients with SZ showed degraded neural M100 responses in A1 during the listen condition, which drove impaired SIS (i.e., smaller M100 listen minus speak differences). Impaired SIS indicated degraded auditory sensory predictions, making it more likely for patients with SZ to misattribute the source of inner thoughts/speech as externally derived, giving rise to disruptions in agency during RM and more severe hallucinations.
Authors
- Judith M. Ford (ORCID: https://orcid.org/0000-0002-6500-6548)
- Songyuan Tan (ORCID: https://orcid.org/0000-0002-6005-5359)
- Daniel H. Mathalon (ORCID: https://orcid.org/0000-0001-6090-4974)
- Srikantan S. Nagarajan (ORCID: https://orcid.org/0000-0001-7209-3857)
- Karuna Subramaniam (ORCID: https://orcid.org/0000-0003-1605-5068)
- Alvincé L. Pongos (ORCID: https://orcid.org/0000-0001-6093-0777)
- Yingxin Jia
- Namasvi Jariwala
- Kurtis Brent
- Miriam Mathew
- John F. Houde
Institutions
- San Francisco VA Medical Center (US)
- Palo Alto University (US)
- University of California, San Francisco (US)
- San Francisco VA Health Care System (US)
- University of San Francisco (US)
Publication Details
- Journal
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.bpsc.2025.10.011
- Citations
- 1
- Primary Topic
- Free Will and Agency
- Type
- article
- Field-Weighted Citation Impact
- 1.43