Sex-specific involvement of calcitonin gene–related peptide signaling for pain in experimental autoimmune encephalomyelitis
These results suggest that targeting peptidergic nociceptors and CGRP signaling, specifically in female patients, may be a viable strategy to relieve and possibly reverse pain in female patients with MS.
Authors
- Jason R. Plemel (ORCID: https://orcid.org/0000-0003-1385-1464)
- Eric R. Willis (ORCID: https://orcid.org/0000-0002-7475-3908)
- Timothy N. Friedman (ORCID: https://orcid.org/0000-0002-0058-5075)
- Gustavo Tenorio
- Aislinn D. Maguire (ORCID: https://orcid.org/0000-0003-4622-4598)
- Bradley J. Kerr (ORCID: https://orcid.org/0000-0002-0264-8316)
- C Stephens
- Daniel Mariano de Andrade (ORCID: https://orcid.org/0009-0007-9779-3404)
- Elise Gosse
- Grayden Kuypers
Institutions
- University of Alberta (CA)
- Women and Children’s Health Research Institute (CA)
Publication Details
- Journal
- PAIN Reports
- Published
- 2025-10-28
- DOI
- https://doi.org/10.1097/pr9.0000000000001350
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00