Evaluation of myocardial classic and alternative pathways of the renin-angiotensin system in cholestasis-induced cardiac injury: A time-course experimental study in rats.
The findings reveal distinct alterations in RAS pathways during cholestasis-induced cardiac injury. The alternative RAS pathway may play a compensatory role in late-stage cholestasis, highlighting potential therapeutic targets for Cholecardia syndrome and cirrhotic cardiomyopathy.
Authors
- Azadeh Khalili (ORCID: https://orcid.org/0000-0003-4455-1843)
- Gholamreza Bayat (ORCID: https://orcid.org/0000-0001-9041-8045)
- Elmira Jafari Afshar (ORCID: https://orcid.org/0000-0001-6561-3324)
- Roham Mazloom (ORCID: https://orcid.org/0000-0003-4873-1374)
- Hossein Karim (ORCID: https://orcid.org/0000-0002-6959-2468)
- Parham Samimisedeh (ORCID: https://orcid.org/0000-0002-3667-8142)
- Mohammad Reza Maleki (ORCID: https://orcid.org/0000-0002-6005-3046)
- Mohammad Jadidian
Institutions
- Jahrom University of Medical Sciences (IR)
- Alborz University of Medical Sciences (IR)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- DOI
- https://doi.org/10.22038/ijbms.2025.87090.18818
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00