Proteomics mechanism and clinical efficacy of Jujuboside A: a Meta-analysis

Objective: To systematically evaluate the mechanism and clinical efficacy of Jujubosid e A in different disease models based on proteomics, and to compare its effect differences in multiple pathological fields by Meta-analysis.Methods: PubMed, Embase, WebofScience, Cochr aneLibrary, CNKI, Wanfang, VIP and China Biology Medicine Disc were searched for relevant studies published from 2005 to 2023.The literature was screened according to prespecified in clusion and exclusion criteria, the data were extracted, and the risk of bias was assessed.Usi ng RevMan Meta analysis, implement indirect comparison and sorting of different mechanism p athways.Results: A total of 35 studies were included, covering five fields: sleep and nerve, metabolic diseases, cancer, inflammation and immunity, and cardiovascular system.Meta analysis showed Jujuboside A have A significant effect in all systems (P < 0.00001), and the heterogen eity is low (I squared = 0%).Conclusion: Jujuboside A exerts its therapeutic effect through m ultiple targets and pathways, and its regulatory network at the proteome level is highly complex and systematic synergistic.The reliability of its cross-disease mechanism and clinical translat ion potential were verified by Meta-analysis, especially supporting its application value in neur ological and metabolic diseases.