Piperacillin dosing in pediatric patients and augmented renal clearance: are current guidelines sufficient to achieve therapeutic concentration coverage?
This study highlights the critical impact of renal function on piperacillin pharmacokinetics in pediatric patients. Continuous infusion regimens are necessary to ensure optimal drug exposure and efficacy, particularly in patients with augmented creatinine clearance. These results emphasize the need to revise pediatric dosing strategies considering a broader range of renal function.
Authors
- Kim Dao (ORCID: https://orcid.org/0000-0002-6033-3435)
- Pierre Alex Crisinel (ORCID: https://orcid.org/0000-0002-1967-8255)
- Ermindo R. Di Paolo (ORCID: https://orcid.org/0000-0003-3843-4528)
- Chantal Csajka (ORCID: https://orcid.org/0000-0002-0660-082X)
- Monia Guidi (ORCID: https://orcid.org/0000-0002-6419-9317)
- Catia Marzolini (ORCID: https://orcid.org/0000-0002-2312-7050)
- Marie‐Hélène Perez (ORCID: https://orcid.org/0000-0001-6173-3396)
- Thierry Buclin (ORCID: https://orcid.org/0000-0003-0639-5536)
- Anne Ravix
- Pascal André
Institutions
- University of Geneva (CH)
- University of Liverpool (GB)
- HES-SO University of Applied Sciences and Arts Western Switzerland (CH)
- University of Basel (CH)
- University Hospital of Basel (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/jac/dkaf387
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00