Perioperative pembrolizumab in early-stage non-small cell lung cancer (NSCLC): conventional and distribution-based immune profiling of the tumor microenvironment and peripheral circulation
This novel, distribution-based analytic framework identified MPR-associated immune cell subsets in baseline PBMC that were not evident using conventional frequency-based immune profiling. Profiling the microenvironment of MPR-associated tumors revealed statistically significant distributional differences among highly expressed cellular markers on CD8<sup>+</sup> cells.
Authors
- Jingxuan Zhang (ORCID: https://orcid.org/0000-0002-8437-6640)
- Katelyn N. Steadman
- Lin Gu (ORCID: https://orcid.org/0000-0002-7504-031X)
- V I Little
- Kent J. Weinhold (ORCID: https://orcid.org/0000-0003-4876-6737)
- Eziafa Oduah (ORCID: https://orcid.org/0000-0001-8517-6360)
- Scott Antonia (ORCID: https://orcid.org/0000-0002-6686-3824)
- Prekshaben Patel (ORCID: https://orcid.org/0000-0002-6216-1534)
- Jennifer Enzor
- Neal Ready
- Lin Lin (ORCID: https://orcid.org/0000-0001-6246-8803)
- Betty Tong (ORCID: https://orcid.org/0000-0002-4135-971X)
Institutions
- Duke University (US)
- Duke University Health System (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1136/jitc-2025-012432
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health