Comparison of One-Year Adverse Events Between First- and Second-Generation Bruton’s Tyrosine Kinase Inhibitors: A Retrospective Study
All BTKi agents were associated with bone marrow suppression, infection, and bleeding, whereas cardiac-related AEs occurred only with IBR. Several Grade 3 or higher events were identified, underscoring the need for careful monitoring of patients receiving BTKi in clinical practice.
Authors
- Kaori Ito (ORCID: https://orcid.org/0000-0001-5276-2064)
- Chisako Iriyama
- Yuichi Hirose (ORCID: https://orcid.org/0000-0002-1305-1830)
- Atushi ITO
- Yoshihiro Inamoto (ORCID: https://orcid.org/0000-0003-4881-0427)
- Shigeki Yamada (ORCID: https://orcid.org/0000-0001-7158-5569)
- Akihiro Tomita (ORCID: https://orcid.org/0000-0002-5391-1399)
- Misaki Morisaku
- Masataka Okamoto
- Nobuki Hayakawa
- Naoe Goto
Institutions
- Fujita Health University (JP)
- Fujita Health University Hospital (JP)
- Meijo University (JP)
Publication Details
- Journal
- Cureus
- Published
- 2025-10-31
- DOI
- https://doi.org/10.7759/cureus.95858
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00