Improving Melanoma Risk Stratification of Skin Color Type by Polygenic Scores of Skin Color and Melanoma
Integrating PGS of skin color and melanoma with the conventional FST classification significantly improves melanoma risk stratification and addresses key limitations of the FST, which, while widely used, lacks sensitivity to intra-type risk variation.
Authors
- Ross M. Levy
- Jianfeng Xu (ORCID: https://orcid.org/0000-0002-1343-8752)
- Zhuqing Shi (ORCID: https://orcid.org/0000-0001-6321-950X)
- David Duggan
- Luzheng Liu
- Aleksandar Sekulić (ORCID: https://orcid.org/0000-0002-1323-3220)
- Jun Wei (ORCID: https://orcid.org/0000-0001-9950-0467)
- S. Lilly Zheng
- Annabelle Ashworth
- Huy Tran (ORCID: https://orcid.org/0009-0006-1648-3280)
Institutions
- Translational Genomics Research Institute (US)
- City Of Hope National Medical Center (US)
- University of Chicago (US)
- Erie Family Health Center (US)
- City of Hope (US)
- Sadick Dermatology (US)
- Center for Genomic Science (IT)
Publication Details
- Journal
- International Journal of Dermatology
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1111/ijd.70121
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00