Nickel-Catalyzed Enantioconvergent Cycloadditions of Aziridines and Imines
Abstract We report asymmetric nickel-catalyzed cycloadditions of aziridines and imines enabled by a newly designed tyrosine-derived FOXAP ligand, delivering up to 97% ee and >20:1 dr. The reaction constructs imidazolidines bearing two nonadjacent stereocenters from racemic vinylaziridines and achiral imines in an enantioconvergent manner.
Authors
- Takuya Kurahashi (ORCID: https://orcid.org/0000-0001-8417-7660)
- Toshifumi Takahashi
- Rihoko Tonbe
- Daishi Hiramatsu
Institutions
- Kwansei Gakuin University (JP)
Publication Details
- Journal
- Synlett
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1055/a-2716-2853
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00