Recent Advances in Endoscopic Ultrasound-Guided Tissue Acquisition

Abstract Endoscopic ultrasound-guided tissue acquisition (EUS-TA) constitutes a pivotal technique in the histopathological evaluation of intra-abdominal and mediastinal lesions. Recent advances enhance the diagnostic yield and clinical utility of EUS-TA. These include the advent of through-the-needle accessories, the integration of molecular and genomic profiling, the implementation of image-enhanced acquisition techniques, and the application of artificial intelligence-assisted image interpretation. Furthermore, the incorporation of digital pathology and telecytology platforms in conjunction with rapid on-site evaluation provides additional value for improving real-time diagnostic assessment. These innovations underscore the evolving role of EUS-TA as a highly adaptable and precision-oriented tool toward individualized patient care in the precision medicine era.