FASTING PLASMA GLUCOSE LEVELS WITHIN THE HIGH NORMAL RANGE ARE ASSOCIATED WITH A SIGNIFICANTLY INCREASED RISK OF FUTURE DYSGLYCEMIA IN TRANSFUSION-DEPENDENT Β THALASSEMIA: A DECADE-LONG MULTICENTER RETROSPECTIVE ANALYSIS

FPG levels at the upper end of the normal range (defined as < 100 mg/dL) in β-TDT patients with severe iron overload are associated with a significantly increased risk for developing either IFG or Th-RDM over a 10-year observational period. The identification of an FPG cutoff (87.5 mg/dL), above which the risk for future dysglycemia increases significantly, could be useful in the routine practice, urging clinicians to intensify iron chelation and monitor these patients more closely.

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Journal
Mediterranean Journal of Hematology and Infectious Diseases
Published
2025-10-31
DOI
https://doi.org/10.4084/mjhid.2025.072
Primary Topic
Hemoglobinopathies and Related Disorders
Type
article
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article

FASTING PLASMA GLUCOSE LEVELS WITHIN THE HIGH NORMAL RANGE ARE ASSOCIATED WITH A SIGNIFICANTLY INCREASED RISK OF FUTURE DYSGLYCEMIA IN TRANSFUSION-DEPENDENT Β THALASSEMIA: A DECADE-LONG MULTICENTER RETROSPECTIVE ANALYSIS

Ploutarchos Tzoulis, Forough Saki, Mohammad Faranoush, Mehran Karimi et al.
Mediterranean Journal of Hematology and Infectious Diseases
Hemoglobinopathies and Related Disorders
article

FASTING PLASMA GLUCOSE LEVELS WITHIN THE HIGH NORMAL RANGE ARE ASSOCIATED WITH A SIGNIFICANTLY INCREASED RISK OF FUTURE DYSGLYCEMIA IN TRANSFUSION-DEPENDENT Β THALASSEMIA: A DECADE-LONG MULTICENTER RETROSPECTIVE ANALYSIS

Ploutarchos Tzoulis, Forough Saki, Mohammad Faranoush, Mehran Karimi, Ashraf Tawfik Soliman, Ihab El-Hakim, Vincenzo De Sanctis, Shahina Daar
article en

Abstract

FPG levels at the upper end of the normal range (defined as < 100 mg/dL) in β-TDT patients with severe iron overload are associated with a significantly increased risk for developing either IFG or Th-RDM over a 10-year observational period. The identification of an FPG cutoff (87.5 mg/dL), above which the risk for future dysglycemia increases significantly, could be useful in the routine practice, urging clinicians to intensify iron chelation and monitor these patients more closely.

Mediterranean Journal of Hematology and Infectious DiseasesVol. 17(1)
American University in Dubai (AE), Iran University of Medical Sciences (IR), Whittington Hospital (GB), Hamad General Hospital (QA), University College London (GB), Sultan Qaboos University (OM)
Openalex Percentile: Top 56%
Hemoglobinopathies and Related Disorders
DOIOpen Access PDFOpenAlex
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FASTING PLASMA GLUCOSE LEVELS WITHIN THE HIGH NORMAL RANGE ARE ASSOCIATED WITH A SIGNIFICANTLY INCREASED RISK OF FUTURE DYSGLYCEMIA IN TRANSFUSION-DEPENDENT Β THALASSEMIA: A DECADE-LONG MULTICENTER RETROSPECTIVE ANALYSIS — Ploutarchos Tzoulis, Forough Saki, et al. · Mediterranean Journal of Hematology and Infectious Diseases (2025) | TGRS Research Map | TGRS