Socioeconomic Status Is Associated With Reward Processing, Interleukin 1β, Striatal Connectivity, and Antidepressant Outcomes in Individuals With Major Depressive Disorder: A CAN-BIND-1 Report
Our results elucidate the role of SES and its negative consequences in altering reward processing and antidepressant treatment efficacy in MDD, corroborating previous literature suggesting that SES significantly impacts health outcomes. Better characterizing the relationship between SES and MDD psychopathology may inform future treatment approaches and intervention development.
Authors
- Gustavo Turecki (ORCID: https://orcid.org/0000-0003-4075-2736)
- Katharine Dunlop (ORCID: https://orcid.org/0000-0003-4366-7692)
- Cláudio N. Soares (ORCID: https://orcid.org/0000-0001-7056-7174)
- Daniel Mueller (ORCID: https://orcid.org/0000-0003-4978-4400)
- Susan Rotzinger (ORCID: https://orcid.org/0000-0003-1980-3674)
- Jane Allyson Foster (ORCID: https://orcid.org/0000-0002-8579-4705)
- Roumen Milev (ORCID: https://orcid.org/0000-0001-6884-171X)
- Sidney H. Kennedy (ORCID: https://orcid.org/0000-0001-5339-7185)
- Sakina J. Rizvi
- Nicholas A. Bock (ORCID: https://orcid.org/0000-0002-4075-0928)
- Benicio Noronha Frey (ORCID: https://orcid.org/0000-0001-8267-943X)
- Stefanie Hassel (ORCID: https://orcid.org/0000-0001-7240-1581)
- Valerie H. Taylor (ORCID: https://orcid.org/0000-0002-8948-638X)
- Nathan Churchill
- Raymond W. Lam (ORCID: https://orcid.org/0000-0001-7142-4669)
- S. Jani
Institutions
- St. Michael's Hospital (CA)
- Centre for Addiction and Mental Health (CA)
- University of British Columbia (CA)
- University of Calgary (CA)
- University of Toronto (CA)
- Queen's University (CA)
- Douglas Mental Health University Institute (CA)
- Occupational Cancer Research Centre (CA)
- Centre for Global Health Research (CA)
- McGill University (CA)
- St. Joseph’s Healthcare Hamilton (CA)
- The University of Texas Southwestern Medical Center (US)
- McMaster University (CA)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100649
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00