Development of Cancer Diagnostics and Treatment using Magnetic Nanoparticles

Magnetic nanoparticles have attracted attention for biomedical applications such as hyperthermia treatment magnetic particle imaging for cancer theranostics. Magnetization dynamics in magnetic nanoparticles determined by the particle structure, applied magnetic field, and surroundings were important for the efficacy of heat generation and signal for magnetic particle imaging. The hysteresis in magnetization response qualified from the area of magnetization curve under an alternating magnetic field was proportional to the heat dissipation. The non-linear response of the magnetization toward the applied magnetic field generated the harmonic magnetization signal. For hyperthermia using magnetic nanoparticles, it is necessary to develop the particle design to enhance the hysteresis derived from the phase delay from the applied magnetic field whose amplitude and frequency were limited considering the safety for the human body. To increase the sensitivity and spatial resolution in magnetic particle imaging, the strongly non-linear magnetization, large gradient magnetic field to select the field free point in the field of view, sensing device, and analytical approach were developed. Moreover, the combination of hyperthermia and magnetic particle imaging was investigated for low invasive and early theranostics.