Synthesis and Biological Activity of Vinyl Derivatives of Pyridoxine
A wide range of pyridoxine derivatives containing vinyl groups at various positions of the pyridine ring were obtained via a three- to ten-step synthesis. Pyridoxine derivatives containing an aromatic hydroxyl and a vinyl group at the second or sixth position of the pyridine ring exhibit high antioxidant activity, which in some cases is comparable to the reference antioxidants such as quercetin, ascorbic acid, and trolox. Cytotoxic activity of the obtained compounds was studied against two conditionally normal and three tumor cell lines.
Authors
- Oleg I. Gnezdilov (ORCID: https://orcid.org/0000-0003-4306-6272)
- Denis Yu. Grishaev (ORCID: https://orcid.org/0000-0001-9311-4661)
- Mikhail V. Pugachev (ORCID: https://orcid.org/0000-0001-9111-2662)
- E. I. Romanova (ORCID: https://orcid.org/0000-0002-2968-8887)
- Yurii G. Shtyrlin (ORCID: https://orcid.org/0000-0002-2777-719X)
- R. M. Khaziev
- Oksana V. Bondar (ORCID: https://orcid.org/0000-0001-9856-5664)
- E. A. Platonova
- R. M. Vafina (ORCID: https://orcid.org/0000-0002-3306-2668)
- A. S. Khristolyubova
Institutions
- Kazan Federal University (RU)
- Kazan Scientific Center (RU)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1134/s1070363225604636
- Primary Topic
- Antimicrobial agents and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00