Probiotic Lactobacillus casei Inhibits Oral Squamous Cell Carcinoma Growth and Induces Apoptosis In Vitro
L. casei exhibits anti-proliferative and apoptotic effects on OSCC. The TRAIL gene upregulation without translation into TRAIL protein suggests a potential caspase-independent mechanism of apoptosis. Further exploration is needed to understand the inhibitory effects of L. casei and its potential as a therapeutic probiotic in OSCC treatment.
Authors
- Maribasappa Karched (ORCID: https://orcid.org/0000-0001-8927-6617)
- Radhika Guleri (ORCID: https://orcid.org/0000-0003-3613-4783)
- Arjuna N.B. Ellepola (ORCID: https://orcid.org/0000-0003-3458-932X)
- Nupur Sharma
- Tawba Abdel Rehaman
Institutions
- Kuwait University (KW)
- American University of Kuwait (KW)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.identj.2025.103960
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 0.00