The JPX/miR-495-3p/BRD4 axis mediates quercetin-induced toxicity via the X-inactivation center in NSCLC
Our findings identify quercetin as a natural compound targeting the JPX-miR-495-3p-BRD4 cascade, providing both mechanistic insights and a translational rationale for quercetin-based NSCLC therapy. These findings highlight the therapeutic potential of quercetin in NSCLC and support further exploration of lncRNA-targeted strategies.
Authors
- X. C. Lou (ORCID: https://orcid.org/0000-0003-0867-2189)
- Jie Wu (ORCID: https://orcid.org/0000-0003-4245-875X)
Institutions
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
Publication Details
- Journal
- Current Research in Toxicology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.crtox.2025.100265
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 0.00