Macrophage Phospholipase D3 promotes atherosclerosis via exacerbating foam cell formation and inducing inflammatory responses
PLD3 is highly expressed in plaque macrophages and promotes atherosclerosis by enhancing CD36-mediated lipid accumulation and activating NF-κB-driven inflammation. These findings identify PLD3 as a potential therapeutic target for atherosclerotic disease.
Authors
- Xuewei Yin (ORCID: https://orcid.org/0000-0002-7480-1025)
- Zixun Wang (ORCID: https://orcid.org/0000-0003-0252-2737)
- Peisong Zhai
- Xiaobao Gu
- Hua Yan (ORCID: https://orcid.org/0000-0002-7651-840X)
- Bing Wang (ORCID: https://orcid.org/0000-0001-8205-4536)
- Li Yang (ORCID: https://orcid.org/0000-0002-2528-5087)
- Li Teng (ORCID: https://orcid.org/0000-0002-8003-490X)
Institutions
- Fifth Affiliated Hospital of Zhengzhou University (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- IJC Heart & Vasculature
- Published
- 2025-10-31
- DOI
- https://doi.org/10.1016/j.ijcha.2025.101834
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00